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Cellular Peptide

Epithalon

EpitalonEpithaloneAEDG PeptideAla-Glu-Asp-GlyCAS: 307297-39-8

A 4-amino acid synthetic tetrapeptide modeled on pineal gland epithalamin that activates telomerase and modulates circadian gene expression in preclinical and early human studies. Premium Direct-Supply Peptide.

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Verified Test Results

Every batch, independently verified.

Each batch is analyzed by an ISO/IEC 17025 accredited third-party laboratory. The report below reflects the identity, purity and full-panel specification data reported by the lab.

ILSILS LaboratoriesCertificate of Analysis≥99%Purity by HPLC
ISO 17025 Accredited8× Tested
ParameterResultMethodSpecification
Peptide Purity (HPLC)99.26%HPLC>= 95%
Net Peptide Content10.32mgHPLCReport
Identity (HPLC)ConfirmedHPLCMeets spec
AppearanceGoodVisualMeets spec
Fentanyl ScreenNot DetectedImmunoassayPass
Heavy Metals (ICP-MS)Not DetectedICP-MSPass
Sterility (PCR)No GrowthPCRPass
Endotoxin (USP <85>)< 0.05 EU/mLUSP <85>Reported

Third-Party Verified

Certificate of Analysis

Every lot is HPLC-tested at an ISO/IEC 17025-accredited lab. Open any batch's certificate below.

COA information

Epithalon 10mg

Latest

LOT EPI0002

99.26%HPLC purity · meets spec
Labeled
10mg
Measured
10.32mg
Identity
Confirmed
Heavy metals
Not Detected
Sterility
No Growth
Endotoxin
< 0.05 EU/mL
Tested
Jul 30, 2026

8 assays passed · ISO/IEC 17025 accredited

Epithalon 10mg

Selected quantity

LOT EPI0001

98.97%HPLC purity · meets spec
Labeled
10mg
Measured
10.44mg
Identity
Epithalon
Heavy metals
Not Detected
Sterility
No Growth
Endotoxin
< 0.05 EU/mL
Tested
Jun 8, 2026

8 assays passed · ISO/IEC 17025 accredited

Certificate of AnalysisEpithalon 10mg · LOT EPI0002
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Compound Information

Technical specifications

MOLECULAR PROFILE

What Is Epithalon?

Type
Synthetic tetrapeptide
CAS Number
307297-39-8
Molecular Weight
390.35 g/mol
Amino Acids
4 (tetrapeptide)
Sequence
Ala-Glu-Asp-Gly (AEDG)
Formula
C₁₄H₂₂N₄O₉

STORAGE REQUIREMENTS

Stability Information

Protect from lightAvoid repeated freeze-thawStore in original sealed vial

Lyophilized (powder)-20°Cup to 2 years

Reconstituted2-8°Cup to 30 days

Product Guides & References

Verified publications and source documentation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties

2025DOI: 10.3390/ijms26062691PMID: 40141333Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł
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BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells

2003DOI: 10.1023/a:1025493705728PMID: 12937682Khavinson VK, Bondarev IE, Butyugov AA
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BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Peptide Promotes Overcoming of the Division Limit in Human Somatic Cells

2004DOI: 10.1023/b:bebm.0000038164.49947.8cPMID: 15455129Khavinson VKh, Bondarev IE, Butyugov AA
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BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Effect of Peptide AEDG on Telomere Length and Mitotic Index of PHA-Stimulated Human Blood Lymphocytes

2019DOI: 10.1007/s10517-019-04664-0Khavinson VKh, Pendina AA, Efimova OA, et al.
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MOLECULES

AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism

2020DOI: 10.3390/molecules25030609PMID: 32019204Khavinson V, Diomede F, Mironova E, et al.
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MECHANISMS OF AGEING AND DEVELOPMENT

Effect of Epitalon on the Lifespan Increase in Drosophila melanogaster

2000Khavinson VKh, Izmaylov DM, Obukhova LK, Malinin VV
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MECHANISMS OF AGEING AND DEVELOPMENT

Effect of Synthetic Thymic and Pineal Peptides on Biomarkers of Ageing, Survival and Spontaneous Tumour Incidence in Female CBA Mice

2001Anisimov VN, Khavinson VKh, Mikhalski AI, Yashin AI
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BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Regulatory Effect of Epithalon on Production of Melatonin and Cortisol in Old Monkeys

2001Goncharova ND, Khavinson BK, Lapin BA
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INTERNATIONAL JOURNAL OF CANCER

Inhibitory Effect of the Peptide Epitalon on the Development of Spontaneous Mammary Tumors in HER-2/neu Transgenic Mice

2002PMID: 12209581Anisimov VN, Khavinson VKH, Provinciali M, et al.
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JOURNAL OF RESTORATIVE MEDICINE

Improving Biological Age, Telomere Length, and Cognition: A Case Study

2024Published case report
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BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Molecular Cellular Mechanisms of Peptide Regulation of Melatonin Synthesis in Pinealocyte Culture

2012Khavinson VK, Linkova NS, Kvetnoy IM, et al.
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ADVANCES IN GERONTOLOGY

AEDG Peptide Prevents Oxidative Stress in the Model of Induced Aging of Skin Fibroblasts

2022Gutop EO, Linkova NS, Kozhevnikova EO, et al.
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